中山大学学报自然科学版 ›› 2016, Vol. 55 ›› Issue (1): 96-101.doi: 10.13471/j.cnki.acta.snus.2016.01.017

• 研究论文 • 上一篇    下一篇

南海珊瑚共附生真菌NG-15-3中蒽醌和含氮类次生代谢产物研究

李秀婷1,刘炳新1,胡谷平2,汪玉梅1,张翠仙1   

  1. 1. 广州中医药大学中药学院,广东 广州 510006; 
    2. 中山大学化学与化学工程学院,广东 广州 510275
  • 收稿日期:2015-09-05 出版日期:2016-01-25 发布日期:2016-01-25
  • 通讯作者: 张翠仙;E-mail:zhangcuixian@aliyun.com

Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea

LI Xiuting1,LIU Bingxin1,HU Guping2,WANG Yumei1,ZHANG Cuixian1   

  1. 1. School of Chinese Material Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China; 
    2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China
  • Received:2015-09-05 Online:2016-01-25 Published:2016-01-25

摘要:

为了研究南海珊瑚共附生真菌NG-15-3次生代谢产物,采用硅胶柱层析和HPLC等分离手段从乙酸乙酯提取部位分离得到单体化合物,结合现代波谱技术、物理常数对照对单体化合物的结构进行结构鉴定。从其分离得到4个蒽醌类:emodin (2)〖STBZ〗、1-O-methyl emodin(3)、physcion (4)、carviolin (5)和6个含氮类次生代谢产物:preechinulin (1)、cyclo-(Phe-Gly) (6)、cyclo-(Gly-Pro)(7)、3Himidazole-4-carboxylic acid (8)、2-methyl-3H-imidazole-4-carboxylic acid (9)和1H-pyrrole-2-carboxylic acid (10)。所有化合物均为首次从该真菌中分离得到,且化合物〖STHZ〗1〖STBZ〗为单去氢2,5-二酮哌嗪类化合物的前体物质,具有丰富的生理活性。

关键词: 珊瑚共附生真菌, NG-15-3, 蒽醌, 含氮类化合物, 结构鉴定

Abstract:

In order to study the secondary metabolites from the coralderived symbiotic fungi NG15-3 of South China Sea, the compounds were isolated by silica gel column chromatography and HPLC. Their structures were identified on the basis of spectral data and physical constant comparison. Four anthraquinones and six nitrogen compounds were isolated as preechinulin (1),emodin (2),1-O-methyl emodin(3),physcion (4),carviolin (5),cyclo-(Phe-Gly) (6),cyclo-(Gly-Pro) (7),3H-imidazole-4-carboxylic acid (8),2-methyl-3H-imidazole-4-carboxylic acid (9) and 1H-pyrrole-2-carboxylic acid (10). All the secondary metabolites were firstly acquired from the coralderived symbiotic fungi NG-15-3 of South China Sea and compound 1 was a precursors of the monodehydro-2,5diketopiperazines,which showed varied biological activity.

Key words: coral-derived symbiotic fungi, NG-15-3, anthraquinones, nitrogen compounds, structural identification

中图分类号: