中山大学学报(自然科学版) ›› 2020, Vol. 59 ›› Issue (4): 19-23.doi: 10.13471/j.cnki.acta.snus.2020.01.09.2020E001

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海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物

郭思雨,邹庭光,朱静琳,林慧美,许婉毅,黄洪波,陶移文
  

  1. 广州医科大学药学院分子靶标和临床药理重点实验室/广州医科大学附属第五医院,广东 广州 511436
  • 收稿日期:2020-01-09 出版日期:2020-07-25 发布日期:2020-07-25
  • 通讯作者: 陶移文(1975年生),男;研究方向:天然药物化学;E-mail:yywentao@aliyun.com
  • 作者简介:郭思雨(1995年生),女;研究方向:天然药物化学;E-mail:654512404@qq.com
  • 基金资助:


Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan

GUO Siyu, ZOU Tingguang, ZHU Jinglin, LIN Huimei, XU Wanyi, HUANG Hongbo, TAO Yiwen   

  1. Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China
  • Received:2020-01-09 Online:2020-07-25 Published:2020-07-25

摘要: 采用大米培养基,对无瓣海桑内生真菌Aspergillus fumigatus SAS10进行静置发酵,运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、以及半制备高效液相等分离手段对发酵产物进行分离纯化,获得7个化合物。经分析质谱、核磁等波谱数据,并通过与文献对比鉴定化合物为:aspergyllone1),(R-2-(羟基(苯基)甲基)-4H-吡喃-4-酮(2),carbonarone A3), campyrone A4),campyrone C5),asperfurandione A6)和 dibutylterephthalate7)。所得7个化合物均为首次报道为烟曲霉次级代谢产物。

关键词: 红树林, 内生真菌, Aspergillus fumigatus, 次级代谢产物, 吡喃酮类化合物

Abstract: The mangrove endophytic fungus Aspergillus fumigatus SAS10 from Sonneratia apetala of Dongzhai haror in Hainan was fermented by using rice medium. The extract of fermentation culture was subjected to column chromatography on silica gel, column chromatography on Sephadex LH-20, and semi-preparative HPLC. Seven compounds were obtained.By analyzing mass and NMR spectroscopic data, their structures were identified as aspergyllone (1), (R)-2-(hydroxy(phenyl)methyl)-4H-pyran-4-one (2), carbonarone A (3), campyrone A (4), campyrone C (5), asperfurandione A (6) and dibutylterephthalate (7), respectively. All of compounds obtained are reported firstly from secondary metabolites of the mangrove endophytic fungus Aspergillus fumigatus.

Key words: mangrove,  , endophytic fungus,  , Aspergillus fumigatus,  , secondary metabolites,  , pyrone

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