中山大学学报(自然科学版) ›› 2020, Vol. 59 ›› Issue (4): 1-6.doi: 10.13471/j.cnki.acta.snus.2020.04.09.2020E008

• •    下一篇

南药猴耳环作为抗生素佐剂的研究进展

刘翀, 王永刚, 李沛波, 彭维, 苏薇薇   

  1. 中山大学生命科学学院/广东省中药上市后质量与药效再评价工程技术研究中心/广东省热带亚热带植物资源重点实验室,广东 广州 510275
  • 收稿日期:2020-04-13 出版日期:2020-07-25 发布日期:2020-07-25
  • 通讯作者: 苏薇薇(1959年生),女;研究方向:创新药物研制、中药上市后再评价及中药国际化;E-mail:lsssww@126.com
  • 基金资助:

Research progress on Pithecellobium clypearia as antibiotic adjuvants

LIU Chong, WANG Yonggang, LI Peibo, PENG Wei, SU Weiwei   

  1. Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
  • Received:2020-04-13 Online:2020-07-25 Published:2020-07-25
  • About author:刘翀(1988年生),男;研究方向:创新药物研制;E-mail:lclchong@hotmail.com

摘要: 本研究团队近年来致力于传统中药新功能开发,从多种中药中筛选出一种具有显著抗生素增效作用的岭南传统中药——猴耳环(Pithecellobium clypearia),其有作为抗生素佐剂的潜力。本文从细菌抗生素耐药现状分析、抗生素佐剂的研究进展以及猴耳环作为抗生素佐剂的研究进展这三个方面,结合本团队的研究成果,对猴耳环作为抗生素佐剂的现状作综述,以期为相关研究提供参考。

关键词: 抗生素多重耐药, 抗生素佐剂, 猴耳环(Pithecellobium clypearia), 协同增效

Abstract: In recent years, our team has been committed to the research of new functions of traditional Chinese medicine, and systematically screened Chinese medicines and identified Pithecellobium clypearia with significant antibiotic synergistic effect, which has the potential to be used as an antibiotic adjuvant. In this review, we summarized the current situation of bacterial antibiotic resistance, the research progress of antibiotic adjuvant, and the research progress of Pithecellobium clypearia as antibiotic adjuvant to provide the reference for the further investigation and development of this herbal plant.

Key words: multiple antibiotic resistance, antibiotic adjuvant; Pithecellobium clypearia, synergistic effect

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