中山大学学报(自然科学版) ›› 2020, Vol. 59 ›› Issue (1): 133-143.doi: 10.13471/j.cnki.jsysusse.2020.01.016

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红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

郑颖琳1 , 佟奕辰1, 孙英英2 , 庞冀燕1   

  1. 1.中山大学化学学院,广东 广州 510275;
    2. 广东省药物新剂型重点实验室/广东药科大学,广东 广州 510006
  • 收稿日期:2019-09-02 出版日期:2020-01-25 发布日期:2020-02-28
  • 通讯作者: 庞冀燕(1973年生),女;研究方向:海洋天然有机化学;E-mail: cespjy@mail.sysu.edu.cn

Secondary metabolites from mangrove fungus  Aspergillus sp. and their biological activities

ZHENG Yinglin 1,TONG Yichen1,SUN Yingying2,PANG Jiyan1   

  1. 1. School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China; 
    2. Guangdong Key Laboratory for New Pharmaceutical Dosage Forms, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Received:2019-09-02 Online:2020-01-25 Published:2020-02-28

摘要: 从曲霉属海洋真菌(〖Aspergillus sp.)中分离出17种化合物 (1-17),其结构由核磁共振波谱(NMR)、质谱(MS)等谱学方法得以确证。其中,化合物1系首次于自然界中被发现,化合物2-17则为已知化合物。对其中部分化合物进行了初步的生物活性测试。其中,化合物对RPMI8226, OCIMY5及MCF-7细胞表现出了中等的抑制活性,化合物10对热应激下的线虫表现出了显著的保护作用。此外,化合物916对化脓性链球菌(Streptococcus pyogenes)表现出轻度的抑制作用,而化合物 17 则对肺炎链球菌(Streptococcus pneumoniae)表现出轻度的抑制作用。


关键词: 海洋真菌, 天然产物, 细胞毒活性, 神经保护活性, 抗菌活性

Abstract: Seventeen compounds (1-17) were isolated from the marine fungus Aspergillus sp. Their structures were determined by nuclear magnetic resonance (NMR) spectroscopy and mass spectrum (MS). Among them, compound 1 was first found as a naturally occurring compound and the known compounds 2-17 were confirmed via spectrum and literatures. The bioactivities of selected compounds were preliminarily evaluated. The compound 2 exhibited moderate inhibitory activities toward three cancer cells, RPMI8226, OCI-MY5, and MCF-7 cells, and compound 10 had significant protective effects on prolonging the survival life of C. elegans under heat stress. In addition, the compound 9 and 16 showed slight inhibition effects against Streptococcus pyogenes and meanwhile the compound 17 possessed slightly inhibitory activity on Streptococcus pneumoniae.


Key words: marine fungus, natural products, cytotoxicity, neuroprotective effects, antibacterial effects

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