红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

doi:10.13471/j.cnki.jsysusse.2020.01.016

中山大学学报(自然科学版) ›› 2020, Vol. 59 ›› Issue (1): 133-143.doi: 10.13471/j.cnki.jsysusse.2020.01.016

红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

郑颖琳¹ , 佟奕辰¹, 孙英英², 庞冀燕¹

1．中山大学化学学院，广东广州 510275；
2. 广东省药物新剂型重点实验室/广东药科大学，广东广州 510006

收稿日期:2019-09-02 出版日期:2020-01-25 发布日期:2020-02-28
通讯作者: 庞冀燕(1973年生)，女；研究方向：海洋天然有机化学；E-mail: cespjy@mail.sysu.edu.cn

Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities

ZHENG Yinglin ¹,TONG Yichen¹,SUN Yingying²，PANG Jiyan¹

1. School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China;
2. Guangdong Key Laboratory for New Pharmaceutical Dosage Forms, Guangdong Pharmaceutical University, Guangzhou 510006, China

Received:2019-09-02 Online:2020-01-25 Published:2020-02-28

摘要/Abstract

摘要： 从曲霉属海洋真菌（〖Aspergillus sp.）中分离出17种化合物 (1-17)，其结构由核磁共振波谱（NMR）、质谱（MS）等谱学方法得以确证。其中，化合物1系首次于自然界中被发现，化合物2-17则为已知化合物。对其中部分化合物进行了初步的生物活性测试。其中，化合物2 对RPMI8226, OCIMY5及MCF-7细胞表现出了中等的抑制活性，化合物10对热应激下的线虫表现出了显著的保护作用。此外，化合物9及16对化脓性链球菌（Streptococcus pyogenes）表现出轻度的抑制作用，而化合物 17 则对肺炎链球菌（Streptococcus pneumoniae）表现出轻度的抑制作用。

关键词: 海洋真菌, 天然产物, 细胞毒活性, 神经保护活性, 抗菌活性

Abstract: Seventeen compounds (1-17) were isolated from the marine fungus Aspergillus sp. Their structures were determined by nuclear magnetic resonance (NMR) spectroscopy and mass spectrum (MS). Among them, compound 1 was first found as a naturally occurring compound and the known compounds 2-17 were confirmed via spectrum and literatures. The bioactivities of selected compounds were preliminarily evaluated. The compound 2 exhibited moderate inhibitory activities toward three cancer cells, RPMI8226, OCI-MY5, and MCF-7 cells, and compound 10 had significant protective effects on prolonging the survival life of C. elegans under heat stress. In addition, the compound 9 and 16 showed slight inhibition effects against Streptococcus pyogenes and meanwhile the compound 17 possessed slightly inhibitory activity on Streptococcus pneumoniae.

Key words: marine fungus, natural products, cytotoxicity, neuroprotective effects, antibacterial effects

中图分类号:

O629

郑颖琳, 佟奕辰, 孙英英, 庞冀燕. 红树林真菌Aspergillus sp. 次级代谢产物及其生物活性[J]. 中山大学学报(自然科学版), 2020, 59(1): 133-143.

ZHENG Yinglin, TONG Yichen , SUN Yingying , PANG Jiyan. Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2020, 59(1): 133-143.

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红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities

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