中山大学学报自然科学版 ›› 2010, Vol. 49 ›› Issue (2): 68-71.

• 研究论文 • 上一篇    下一篇

中国南海红树内生真菌Microsphaeropsis sp.二氢异香豆素类化合物研究

魏美燕1,胡谷平2,郑彩娟3,邵长伦3,王长云3,周世宁2,佘志刚2,林永成2   

  1. (1广东医学院药学院,广东 东莞 523808;2中山大学化学与化学工程学院,广东 广州 510275;3中国海洋大学医药学院,山东 青岛 266003)
  • 收稿日期:2009-09-21 修回日期:1900-01-01 出版日期:2010-03-25 发布日期:2010-03-25

Dihydroisocoumarin Derivatives of Mangrove Endophytic Fungus Microsphaeropsis sp. Isolated from the South China Sea

WEI Meiyan1, HU Guping2, ZHENG Caijuan3, SHAO Changlun3, WANG Changyun3, ZHOU Shining2 ,SHE Zhigang2, LIN Yongcheng2   

  1. (1School of Pharmacy, Guangdong Medical College, Dongguan 523808, China;2School of Chemistry and Chemical Engineering, Sun Yatsen University, Guangzhou 510275, China; 3School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • Received:2009-09-21 Revised:1900-01-01 Online:2010-03-25 Published:2010-03-25

摘要:

首次研究了一株南海红树内生真菌Microsphaeropsis sp.的次级代谢产物。从该菌的培养液的乙酸乙酯相中分离获得8个二氢异香豆素单体化合物,运用现代波谱技术鉴定其结构分别为4hydroxy8Omethylmellein (1),mellein (2), 4hydroxymellein (3), 5hydroxymellein (4), 4hydroxy3,5dimethylmellein (5), 5methylmellein (6), 7hydroxymellein (7), 5carboxymellein (8)。其中,化合物1为从自然界发现的新天然产物,化合物 4,5,6,7,8 为首次从海洋真菌Microsphaeropsis sp.中分离得到的化合物。

关键词: 红树林内生真菌, 次级代谢产物, 二氢异香豆素

Abstract:

The secondary metabolites of the mangrove endophytic fungus Microsphaeropsis sp. from the South China Sea were first studied. Eight dihydroisocoumarin derivatives were isolated from the ethyl acetate extract of the fermentation. Their structures were identified by comprehensive spectroscopic methods as 4 hydroxy8 Omethylmellein (1), mellein (2), 4hydroxymellein (3), 5hydroxymellein (4), 4hydroxy3,5dimethylmellein (5), 5methylmellein (6), 7 hydroxymellein (7) and 5 carboxymellein (8). Compound 1 was isolated as a natural compound for the first time and compounds 4,5,6,7,8 were first isolated from the fungus Microsphaeropsis sp.

Key words: mangrove endophytic fungus, secondary metabolites, dihydroisocoumarin

中图分类号: