中山大学学报自然科学版 ›› 2011, Vol. 50 ›› Issue (1): 70-74.

• 研究论文 • 上一篇    下一篇

毛冬青中三萜皂苷类化合物的分离(Ⅲ)

张翠仙,林朝展,杨金燕,熊天琴,邓洁薇,韦瑀龙,赵钟祥,祝晨蔯   

  1. (广州中医药大学中药学院,广东 广州510006)
  • 收稿日期:2010-08-15 修回日期:1900-01-01 出版日期:2011-01-25 发布日期:2011-01-25

Triterpene Saponins Isolated from Ilex pubescens (Ⅲ)

ZHANG Cuixian, LIN Chaozhan, YANG Jinyan, XIONG Tianqin, DENG Jiewei, WEI Yulong, ZHAO Zhongxiang, ZHU Chenchen   

  1. (Guangzhou University of Chinese Medicine, School of Traditional Chinese Pharmacy, Guangzhou 510006,China)
  • Received:2010-08-15 Revised:1900-01-01 Online:2011-01-25 Published:2011-01-25

摘要: 药理活性研究表明,毛冬青总皂苷不仅具有明显降低血浆粘度的作用,而且还能明显抑制兔离体动脉条的收缩。继续对其总皂苷的化学成分进行研究,从其正丁醇萃取部位分离得到5个三萜皂苷类化合物,经理化性质及波谱方法鉴定为:mussaendoside R(1)、ziyu-glycoside I (2)、Lucyoside H(3)、ilexoside A(4)、ilexoside O (5)。其中1、2、3为首次从该植物中分离得到。

关键词: 毛冬青, 三萜皂苷类化合物, 结构研究

Abstract: Traditional chinese medicine of Ilex pubescens (Mao-Dong-Qing) is commonly used to treat the cardiovascular diseases in South China. The preliminary bioassays showed that the total saponins isolated from Ilex pubescens exhibited significant potent degrading the plasma viscosity in rats. Meanwhile, our recent works indicated that the n-BuOH soluble fractions of ethanol extract (70%) from the root of the same species obviously inhibited the contraction (60 μg/mL) of rabbit thoracic aorta induced by norpinephrine in vitro. As a continuation of bioactive constituent from the n-BuOH of Ilex pubescens, five triterpene saponins were isolated. Their structures were elucidated by chemical, physical methods and spectroscopic analysis methods. As a result, they were identified as mussaendoside R (1), ziyu-glycoide I (2), Lucyoside H (3), ilexoside A (4), ilexoside O (5), excepescially. Compounds 1, 2 and 3 were firstly obtained from Ilex pubescens.

Key words: Ilex pubescens, triterpene saponins, structure

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