中山大学学报自然科学版 ›› 2011, Vol. 50 ›› Issue (6): 58-61.

• 研究论文 • 上一篇    下一篇

含纳米银的抗菌水凝胶研究

杨立群1,林凯城1,沈荣春1,马 林1,张黎明1,卢 亢2   

  1. (1.中山大学化学与化学工程学院//聚合物复合材料及功能材料教育部重点实验室//新型聚合物材料设计合成与应用广东省高校重点实验室,广东 广州 510275;2. 广东泰宝科技医疗用品有限公司,广东 普宁 515300)
  • 收稿日期:2011-07-13 修回日期:1900-01-01 出版日期:2011-11-25 发布日期:2011-11-25

Silver Nanoparticlesbased Antibacterial Hydrogels

YANG Liqun1, LIN Kaicheng1, SHEN Rongchun 1, MA Lin1, ZHANG Liming1, LU Kang2   

  1. (1. School of Chemistry and Chemical Engineering//DSAPM Lab//PCFM Lab,Sun Yatsen University, Guangzhou 510275, China; 2. Guangdong TaiBao Corporation of Medical Technology, Guangdong Pulin 515300,China)
  • Received:2011-07-13 Revised:1900-01-01 Online:2011-11-25 Published:2011-11-25

摘要: 为赋予水凝胶的抗菌性能,该文对含有纳米银的水凝胶进行了研究。首先在硝酸银溶液加入硼氢化钠还原剂和聚乙烯砒咯烷酮分散剂,合成纳米银;然后将不同体积的纳米银分散液加入到卡波姆溶液中,搅拌下滴加氢氧化钠溶液,制备含纳米银的水凝胶。紫外-可见光谱法的结果表明硝酸银被还原成纳米银,X-射线粉末衍射法证实纳米银被分散在水凝胶中,并通过Scherrer公式计算出纳米银的尺寸约为5 nm。溶胀性能测试结果表明水凝胶的溶胀率约为900%。抑菌性能测试结果显示,当水凝胶中纳米银浓度为10 μg/mL(低于纳米银的安全浓度25 μg/mL),水凝胶能有效抑制大肠杆菌和金黄色葡萄球菌的生长。所制备的抗菌水凝胶可望应用于创伤皮肤和皮肤疾病的外用治疗。

关键词: 水凝胶, 纳米银, 卡波姆, 抗菌性能, 溶胀性能

Abstract: The silver nanoparticlesbased hydrogels were investigated in order to increase the antibacterial property in this work. The silver nanoparticles were synthesized in aqueous silver nitrate solution by adding sodium borohydride as a reduction reagent and polyvinyl pyrrolidone as a dispersion aid. And then the silver nanoparticlesbased hydrogels were further prepared in the carbomer solution by adding the dispersion solutions of silver nanoparticles with different volumes and sodium hydroxide solution. The result of UVvis analysis indicated that the silver nanoparticles were successfully synthesized. The existence of silver nanoparticles in the hydrogels was confirmed by Xray scattering analysis, and the diameters of silver nanoparticles were calculated to be about 5 nm according to the Scherrer equation. The swelling ratio of the hydrogels was determined to be 900%. The hydrogels exhibited strong antibacterial properties to Escherichia coli and Staphylococcus aureus with the content of silver nanoparticles 10 μg/mL, which is lower than the safe content of silver nanoparticles 25 μg/mL. The hydrogels are thus anticipated to be used for the treatment of wounded skin and skin disease.

Key words: hydrogel, silver nanoparticle, carbomer, antibacterial property, swelling property

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