中山大学学报自然科学版 ›› 2011, Vol. 50 ›› Issue (6): 72-77.

• 研究论文 • 上一篇    下一篇

软珊瑚Sarcophyton tortuosum共生真菌penicillium sp.的代谢产物研究

王 丰1,李厚金2,蓝文健1

  

  1. (1. 中山大学药学院,广东 广州 510006;2. 中山大学化学与化学工程学院,广东 广州 510275)
  • 收稿日期:2011-07-26 修回日期:1900-01-01 出版日期:2011-11-25 发布日期:2011-11-25
  • 通讯作者: 蓝文健

The Metabolites of the Marine Fungus Penicillium sp. Associated with Soft Coral Sarcophyton tortuosum

WANG Feng1,LI Houjin2,LAN Wenjian1   

  1. (1. School of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou 510006, China; 2. School of Chemistry and Chemical Engineering, Sun Yatsen University, Guangzhou 510275, China)
  • Received:2011-07-26 Revised:1900-01-01 Online:2011-11-25 Published:2011-11-25

摘要: 从三亚采集的软珊瑚Sarcophyton tortuosum体内分离得到一株共生真菌Penicillium sp.,该菌在GPY培养基中培养,菌体呈浅红色。对该菌菌体的代谢产物进行了研究,纯化得到1个新化合物:(4E,6E)-2-N-十六碳酰基-1,3-二羟基十六烷-4,6-二烯-鞘胺醇 (1),以及4个已知化合物1,7-二羟基-3-甲氧基-6-甲基-蒽醌(2),1,7,8-三羟基-3-甲氧基-6-甲基-蒽醌(3),1-羟基-3-甲氧基-6-甲基-蒽醌(4),4,8-二甲基-1,5-二氧环辛烷-2,6-二酮(5)。化合物结构主要通过MS,NMR等波谱数据分析确定。化合物2,3,4,5〖STBZ〗为首次从海洋真菌中分离得到。

关键词: 海洋真菌, Penicillium sp., (4E, 6E)-2-N-十六碳酰基-1, 3-二羟基十六烷-4, 6-二烯-鞘胺醇, 蒽醌

Abstract: Marine fungus Penicillium sp. was isolated from the soft coral Sarcophyton tortuosum collected in the South China Sea. While cultured in GPY medium, the fungal mycelia were reddish. Five compounds including (4E,6E) 2-N-hexadecanoyl-1,3-dihydroxyhexadeca-4,6-dien sphingosine(1), 1,7-dihydroxy-3-methoxy-6-methyl -anthraquinone macrosporin (2), 1,7,8- trihydroxy- 3- methoxy-6-methyl- anthraquinone (3), 1-hydroxy-3-methoxy-6-methyl-anthraquinone (4) and 4,8- dimethyl-1,5-dioxocane-2,6-dione (5)were obtained from the methanol extract of the fungal mycelia. Their structures were characterized by MS and NMR analyses. The result indicated that the compound (1) was a new compound, and the compounds 2,3,4,5 were first isolated from the marine fungus.

Key words: marine fungus, Penicillium sp., (4E, 6E)2-N-Hexadecanoyl-1, 3- dihydroxyhexadeca- 4, 6-dien sphingosine, anthraquinone

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