中山大学学报自然科学版 ›› 2018, Vol. 57 ›› Issue (3): 89-95.

• 论文 • 上一篇    下一篇

毛麝香的化学成分研究(Ⅱ)

于思1,彭光天1,雷玉1,薛岱榆1,冼建春2,张翠仙1,何细新1   

  1. 1. 广州中医药大学中药学院,广东 广州 510006;
    2. 广东中医药博物馆,广东 广州 510006
  • 收稿日期:2017-12-01 出版日期:2018-05-25 发布日期:2018-05-25
  • 通讯作者: 何细新(1972年生),男;研究方向:中药及天然药物活性;E-mail:mark07@gzucm.edu.cn

Chemical constituents of Adenosma glutinosum(Ⅱ)

YU Si1, PENG Guangtian1, LEI Yu1, XUE Daiyu1, XIAN Jianchun2, ZHANG Cuixian1, HE Xixin1    

  1. 1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guanghzhou 510006, China;
    2. Guangdong Chinese Medicine Museum, Guangzhou University of Chinese Medicine, Guanghzhou 510006, China
  • Received:2017-12-01 Online:2018-05-25 Published:2018-05-25

摘要:

采用硅胶、凝胶、半制备液相等分离技术,对毛麝香 Adenosma glutinosum(L.) Druce乙醇提取物的乙酸乙酯、石油醚以及正丁醇部位进行化学成分研究,从中分离得到了12个化合物。根据核磁共振、质谱等谱图数据和文献对照等研究方法,鉴定化合物结构分别为:30-醛基-白桦脂酸(1),1,3,5-三甲氧基苯(2),3,5-二甲氧基苯乙酮(3),β-谷甾醇(4),豆甾醇(5),大黄素甲醚(6),芝麻素(7),早熟素Ⅱ(8),棕榈酸(9),正二十六醇(10),D-阿洛醇(11),芹菜素-7-O-β-D-葡萄糖醛酸丁酯(12)。所有化合物均为首次从毛麝香属中分离得到。

关键词: 毛麝香, 化学成分, 结构鉴定

Abstract:

In order to investigate the chemical constituents from Adenosma glutinosum comprehensively, the chemical ingredients of the ethyl acetate, petroleum and nbutanol fraction of the extracts were isolated. Then, twelve compounds were obtained by various chromatographic techniques. Their structures were determined by spectroscopic analysis and literature comparison method, they were: 30-oxo-betulinic acid (1), 1,3,5-trimethoxybenzene (2), 3,5-dimethoxyacetophenone (3), β-sitosterol (4), stigmasterol (5), physcion (6), sesamin (7), precocene Ⅱ (8), palmitic acid (9), hexacosyl alcohol (10), D-allitol(11), apigenin-7-O-β-D-glucuronide butyl ester(12), respectively. All compounds were isolated from this plant for the first time.

Key words: Adenosma glutinosum (L.) Druce, chemical constituents, structure identification

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