盐酸环丙沙星在不同模拟水体中的降解与残留

中山大学学报自然科学版 ›› 2010, Vol. 49 ›› Issue (3): 102-106.

盐酸环丙沙星在不同模拟水体中的降解与残留

李霞^1，陈菊芳^1，聂湘平^2，林建锋^1，周孝治^1

（1. 暨南大学理工学院，广东广州 510632； 2. 暨南大学生命科学技术学院，广东广州 510632）

收稿日期:2009-11-01 修回日期:1900-01-01 出版日期:2010-05-25 发布日期:2010-05-25
通讯作者: 陈菊芳

Degradation and Residue of Ciprofloxacin in Different Simulated Water Bodies

LI Xia^1, CHEN Jufang¹, NIE Xiangping², LIN Jianfeng^1, ZHOU Xiaozhi^1

(1. College of Science and Engineering, Jinan University, Guangzhou 510632, China;2. Institute of Hydrobiology, Jinan University, Guangzhou 510632, China)

Received:2009-11-01 Revised:1900-01-01 Online:2010-05-25 Published:2010-05-25

摘要/Abstract

摘要： 通过反相高效液相色谱法研究在不同模拟水体中，溶液质量浓度、pH对盐酸环丙沙星（CPFX）在水和底泥中含量变化的影响，分析其在模拟水体中降解和残留规律。研究结果表明：在1、5、10 mg·L^-1三个CPFX溶液质量浓度中，光降解度最高的溶液质量浓度为1 mg·L^-1，自然光照下，72 h后盐酸环丙沙星在有底泥和无底泥的水体中残留率分别为19 %和20 %，光降解率与初始质量浓度成反比。在pH分别为3、5、9、11条件下，pH=9的微碱性环境下最易光降解，而当pH=3时其光稳定性最佳，48 h后水体残留率分别为22.6 %和95.7 %。盐酸环丙沙星进入模拟水生态系统后，水体中CPFX质量浓度迅速下降，45 d后检测不到它的存在；底泥中CPFX质量分数迅速上升，之后缓慢下降，45 d后底泥中仍有一定残留量，达到93.86 μg·kg^-1。

关键词: 盐酸环丙沙星, 光降解, 微宇宙模拟水生态系统

Abstract: The influence of drug concentration and pH on the photodegradation of ciprofloxacin was investigated, and a reversephase highperformance liquid chromatographic method was developed for detecting the changes of ciprofloxacin content in water and sediments. Photodegradation of ciprofloxacin in natural light was most rapid at a concentration of 1 mg·L^-1 among the three concentrations tested (1,5 and 10 mg·L^-1). After 72 h, the amounts of ciprofloxacin remaining with and without sediments were 19% and 20%, respectively. The photodegradation rate was inversely proportional to the initial drug concentration. Ciprofloxacin was most sensitive to photodegradation at pH 9 among the four pH levels tested 〖JP2〗(pH =3, 5, 9, 11), when the〖JP〗 drug was in zwitterionic form. The stability increased considerably when pH=3. After 48 h, the amounts of ciprofloxacin remaining in water were 22.6 % and 95.7%, respectively. When ciprofloxacin was released into microcosms, the concentration of ciprofloxacin in water decreased rapidly, but increased concomitantly in sediments. After 45 days ciprofloxacin was undetectable in water, but a substantial concentration remained in the sediments.(approximately 93.86 μg·kg^-1).

Key words: ciprofloxacin hydrochloride, photodegradation, microcosmos system

中图分类号:

李霞;陈菊芳;聂湘平;林建锋;周孝治. 盐酸环丙沙星在不同模拟水体中的降解与残留[J]. 中山大学学报自然科学版, 2010, 49(3): 102-106.

LI Xia;CHEN Jufang;NIE Xiangping;LIN Jianfeng;ZHOU Xiaozhi. Degradation and Residue of Ciprofloxacin in Different Simulated Water Bodies[J]. , 2010, 49(3): 102-106.