Acta Scientiarum Naturalium Universitatis Sunyatseni ›› 2020, Vol. 59 ›› Issue (4): 19-23.doi: 10.13471/j.cnki.acta.snus.2020.01.09.2020E001

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Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan

GUO Siyu, ZOU Tingguang, ZHU Jinglin, LIN Huimei, XU Wanyi, HUANG Hongbo, TAO Yiwen   

  1. Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China
  • Received:2020-01-09 Online:2020-07-25 Published:2020-07-25

Abstract: The mangrove endophytic fungus Aspergillus fumigatus SAS10 from Sonneratia apetala of Dongzhai haror in Hainan was fermented by using rice medium. The extract of fermentation culture was subjected to column chromatography on silica gel, column chromatography on Sephadex LH-20, and semi-preparative HPLC. Seven compounds were obtained.By analyzing mass and NMR spectroscopic data, their structures were identified as aspergyllone (1), (R)-2-(hydroxy(phenyl)methyl)-4H-pyran-4-one (2), carbonarone A (3), campyrone A (4), campyrone C (5), asperfurandione A (6) and dibutylterephthalate (7), respectively. All of compounds obtained are reported firstly from secondary metabolites of the mangrove endophytic fungus Aspergillus fumigatus.

Key words: mangrove,  , endophytic fungus,  , Aspergillus fumigatus,  , secondary metabolites,  , pyrone

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