Acta Scientiarum Naturalium Universitatis Sunyatseni

   

Prenylated xanthones from the pericarps of Garcinia mangostana

TANG Zhuoya1, PAN Yuehua1, ZHANG Junsheng2, YIN Sheng1, TANG Guihua1   

  1. 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;
    2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China

  • Received:2020-03-05 Online:2020-07-08 Published:2020-07-08

Abstract:

Phytochemical investigation on the pericarps of Garcinia mangostana resulted in the isolation of 22 xanthones. On the basis of the spectroscopic data, the structures of these known compounds were identified as 1,3,7-trihydroxyxanthone (1), 1,3,6,7-tetrahydroxy-8-prenylxanthone (2), 1,3,5-trihydroxy-4-prenylxanthone (3), 8-deoxygartanin (4), cudraxanthone G (5), gartanin (6), 6-deoxy-γ-mangostin (7), γ-mangostin (8), α-mangostin (9), 1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone (10)β-mangostin (11), garcinone D (12), garcinone B (13), mangostenone D (14), 3-O-methylmangostenone D (15), 9-hydroxycalabaxanthone (16), 11-hydroxy-1-isomangostin (17), brasilixanthone B (18), garcimangosxanthone D (19), BR-xanthone A (20), tovophyllin A (21), and 1,3,6-trihydroxy-2,5-bis(3-methylbut-2-enyl)-6',6'-dimethyl-4',5'-dihydropyrano[2,3':7,8]xanthone (22). Compounds 2-22 were prenylated xanthones, and 3 and 15 were isolated from this plant for the first time. The neuroprotective effects of all compounds against glutamate-induced cell death were tested in murine hippocampal neuronal cell line HT22.

Key words:

Guttiferae, Garcinia mangostana, prenylated xanthones, neuroprotective activity

CLC Number: