Acta Scientiarum Naturalium Universitatis Sunyatseni

   

Mechanisms of “Astragalus membranaceus - Atractylodes macrocephala koidz” for the treatment of lung cancer based on network pharmacology

LIU Zishen1,2, YANG Guowang1   

  1. 1. Department of Oncology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;
    2. Capital Medical University,Beijing 100069,China


  • Received:2020-04-27 Online:2020-07-03 Published:2020-07-03

Abstract:

The study aimed to explore the possible mechanism of “Astragalus membranaceus - Atractylodes macrocephala koidz” for the treatment of lung cancer through network pharmacologyThe active ingredients of “Astragalus membranaceus - Atractylodes macrocephala koidz ” were queried through the TCMSP database, the targets of the active ingredients were screened through the TCMSP database, and the targets were standardized and named through the Uniprot database. The lung cancer related targets were queried through the “TTD” database, “DisGeNET” database and “OMIM” database. The “compound-disease” common targets were obtained using Venn Diagram, and the protein interaction network (PPI) was constructed using STRING database, and R language was used for GO enrichment analysis and KEGG pathway enrichment analysis.“Astragalus membranaceus-Atractylodes macrocephala koidz” drugs were screened to obtain 19 active ingredients, 180 potential targets, 29 potential targets for the treatment of lung cancer, including AKT1,VEGFA,EDFR,etc. GO functional enrichment was analyzed and screened according to P <0.05, which involved 1 260 biological processes, 12 cell groups, 32 molecular functions, such as reactive oxygen species metabolic process, response to steroid hormone, regulation of apoptotic signaling pathway, T cell activation, etc. KEGG signal pathway enrichment was analyzed and screened according to P <0.05, involving 26 signal pathways, including PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance, Platinum drug resistance, HIF-1 signaling pathway, MAPK signaling pathway, Cellular senescence, Rap1 signaling pathway, Ras signaling pathway, etc." Astragalus membranaceus - Atractylodes macrocephala koidz " plays a role in inhibiting tumor angiogenesis, inducing tumor cell apoptosis and inhibiting tumor metastasis by regulating signaling pathways and anti-cancer drug resistance, thereby treating lung cancer. “Astragalus membranaceus-Atractylodes macrocephala koidz” involves multiple active ingredients, multiple targets and multiple signaling pathways in the treatment of lung cancer.

Key words:

network pharmacology, lung cancer, Astragalus membranaceus - Atractylodes macrocephala koidz, mechanism of action

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